We work at the intersection of bioengineering and genomics to invent new tools for understanding and treating genetic disorders.
The Hsu Lab aims to understand and manipulate the genetic circuits that control brain and immune cell function to improve human health. We explore the rich biological diversity of nature to create new molecular technologies for genome and transcriptome engineering, perturb complex cellular processes at scale, and develop next-generation gene and cell therapies. To do this, our group draws from a palette of technologies including CRISPR-Cas, engineered viruses, genome sequencing, massively parallel reporter assays, and pooled genetic screens.
Our work is supported by the University of California at Berkeley, the NIH Director's Early Independence Award, the National Institute on Aging, NIGMS, Dipanjan and Shashikala Deb, the Curci Foundation, Fastgrants, and the Rainwater Foundation. We are housed within the Innovative Genomics Institute.
Our lab receives a second R01, for structure-function studies of CRISPR systems. Thank you to the NIH for the support.
Alison Fanton is named a NSF Graduate Fellow. Congratulations, Alison!
Our study of COVID-19 antibody tests is now published in Nature Biotechnology.
The lab is funded by Fastgrants for COVID-19 therapeutic and diagnostic development
Our pre-print on validating serology tests for SARS-CoV-2 is online at https://covidtestingproject.org/ and highlighted in the New York Times, CNN, The Scientist, Berkeley News, CBS, Yahoo News, and The Guardian.
Thank you to the Curci Foundation for funding our COVID-19 response effort at IGI!
We are hiring at all levels (postdocs, graduate students, research assistants)! If you're interested in joining our lab, visit our Join us page.
Our CasRx plasmids are all Blue Flame on Addgene, and have been distributed to over 250 labs worldwide! Get them here: https://www.addgene.org/Patrick_Hsu/
Peter Lotfy joins Harvard BBS for his PhD studies. Go Peter!
Eleanor Wang, an undergrad in the lab, wins the 2019 Barry Goldwater Scholarship.
Congratulations to Eleanor!
Tom Alsaigh is named a KL2 Clinical Scholar! Go Tom!