Editing biology to understand life

We work at the intersection of bioengineering and genomics to invent new tools for understanding and treating genetic disorders.


The Hsu Lab aims to understand and manipulate the genetic circuits that control brain and immune cell function to improve human health. We explore the rich biological diversity of nature to create new molecular technologies for genome and transcriptome engineering, perturb complex cellular processes at scale, and develop next-generation gene and cell therapies. To do this, our group draws from a palette of technologies including CRISPR-Cas, engineered viruses, genome sequencing, massively parallel reporter assays, and pooled genetic screens.

Our work is supported by DARPA, the NIH Director's Early Independence Award, the National Institute on Aging, NIGMS, Dipanjan and Shashikala Deb, the Curci Foundation, Emergent Ventures, and the Rainwater Foundation.

Our lab is physically located at the Arc Institute in Stanford Research Park and the Innovative Genomics Institute at UC Berkeley, and additionally affiliated with the California Institute for Quantitative Biosciences (QB3), Berkeley Stem Cell Center, UC Berkeley-UCSF Graduate Program in Bioengineering, Center for Computational Biology and CCB PhD Program, and Biophysics Graduate Program.